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Development and Evaluation of Sustained Release Lipid Nanocarriers for Curcumin

[ Vol. 5 , Issue. 3 ]

Author(s):

Harshal A. Pawar* and Bhagyashree D. Bhangale   Pages 224 - 235 ( 12 )

Abstract:


Background: Lipid based excipients have increased acceptance nowadays in the development of novel drug delivery systems in order to improve their pharmacokinetic profiles. Drugs encapsulated in lipids have enhanced stability due to the protection they experience in the lipid core of these nano-formulations. Phytosomes are newly discovered drug delivery systems and novel botanical formulation to produce lipophilic molecular complex which imparts stability, increases absorption and bioavailability of phytoconstituent. Curcumin, obtained from turmeric (Curcuma longa), has a wide range of biological activities. The poor solubility and wettability of curcumin are responsible for poor dissolution and this, in turn, results in poor bioavailability. To overcome these limitations, the curcumin-loaded nano phytosomes were developed to improve its physicochemical stability and bioavailability.

Objective: The objective of the present research work was to develop nano-phytosomes of curcumin to improve its physicochemical stability and bioavailability.

Methods: Curcumin-loaded nano phytosomes were prepared by using phospholipid Phospholipon 90 H using a modified solvent evaporation method. The developed curcumin nano phytosomes were evaluated by particle size analyzer and differential scanning calorimetry (DSC).

Results: Results indicated that phytosomes prepared using curcumin and lipid in the ratio of 1:2 show good entrapment efficiency. The obtained curcumin phytosomes were spherical in shape with a size less than 100 nm. The prepared nano phytosomal formulation of curcumin showed promising potential as an antioxidant.

Conclusion: The phytosomal complex showed sustained release of curcumin from vesicles. The sustained release of curcumin from phytosome may improve its absorption and lowers the elimination rate with an increase in bioavailability.

Keywords:

Phytosomes, curcumin, soyabean phospholipid, antioxidant, zingiberaceae, phospholipon 90 H.

Affiliation:

Department of Pharmacognosy/Quality Assurance, Dr. L.H. Hiranandani College of Pharmacy, Ulhasnagar-421003, Maharashtra, Department of Quality Assurance, Dr. L.H. Hiranandani College of Pharmacy, Ulhasnagar-421003, Maharashtra

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