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Doping of ZnO Nanoparticles with Curcumin: pH Dependent Release and DPPH Scavenging Activity of Curcumin in the Nanocomposites

[ Vol. 3 , Issue. 3 ]

Author(s):

Oussama Nasrallah, Riham El Kurdi, Mai Mouslmani and Digambara Patra*   Pages 147 - 152 ( 6 )

Abstract:


Background and Objective: Curcumin doped ZnO (Zn(cur)O) has been successfully synthesized and characterized through a simple method.

Method: Formed Zn(Cur)O nanocomposites have been found to be stable and crystalline in a wurtzite hexagonal structure. The release of curcumin from the Zn(cur)O is triggered by pH where basic environment triggers maximum release compared to acidic and neutral conditions. There is a 2-fold enhancement in the rate constant during curcumin release from Zn(cur)O in pH 8 compared to that in pH 6 or pH 5. The drug release profile of curcumin from the Zn(cur)O obeys the Higuchi model. The antioxidant activity of Zn(cur)O has been examined according to DPPH radical scavenging activity.

Results and Conclusion: As expected, free radical scavenging activity of Zn(cur)O on DPPH increases with Zn(cur)O concentration, thus, Zn(cur)O demonstrates moderate antioxidant effect by scavenging 70% at 2 mg/mL of Zn(cur)O, which indicates that Zn(cur)O can be potentially utilized as a vehicle for curcumin release by keeping its biological activities intact.

Keywords:

Curcumin, ZnO, nano-composites, drug delivery, scavenging activity, pH.

Affiliation:

Department of Chemistry, American University of Beirut, Beirut, Department of Chemistry, American University of Beirut, Beirut, Department of Chemistry, American University of Beirut, Beirut, Department of Chemistry, American University of Beirut, Beirut

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