Enza Fazio*, Alessandro Ridolfo and Giulia Neri Pages 1 - 11 ( 11 )
Nanosystems based on PEG-PLGA copolymer have attracted increasing interest in several biomedicine fields, due to their unique properties. Commonly, PEG-PLGA copolymer was used to formulate nanoparticles (NPs) for drug delivery applications. Only recently, the engineering of polymeric nanofibrous membrane able to be used like drug nanocarrier was investigated. Herein, the development of two new drug delivery systems based on PEGylated-PLGA nanofibrous scaffolds, obtained by electrospinning deposition, simultaneously loaded with: i) silibinin, a therapeutic agent, ii) Au/Ag and iii) non-toxic Fe2O3 magnetic nanoparticles, is reported. In these systems both the time release and the amount of drug released at a specific target site can be fine-tuned by two external stimuli: a light source and a magnetic field, respectively. Moreover, the use of “Surface Plasmon Resonance”- mediated localized photothermal effect, determined by the nanoparticles resonant absorption of visible radiation, allows to our systems to be able to employ for photothermal drug delivery therapies in the proximity of tumor cells. Another interesting aspect of the present work regards how the morphological structure can influence the drug release. All data obtained about the fiber scaffolds are compared to NPs based on the same PEG-PLGA copolymer, loaded with silibinin, Fe2O3 and Au/Ag nanoparticles alternatively, reported in a previous work. Thus, nanofibers with respect to NPs, showed interesting sustained responsive silibinin release for at least 60 h, without the burst effect. To support these evidence, a mathematical model describing the release mechanisms was developed. In conclusion, nanofibers showed the better results with respect to the corresponding NPs.
Metal-polymeric composite, ferromagnetic nanomaterials, electrospun nanofibrous membranes, pulsed laser ablation, silibinin, stimuli-responsive drug release, laser irradiation.
Messina University, Dipartimento di Scienze Matematiche e Informatiche, Scienze Fisiche e Scienze della Terra, Universita di Messina, RIKEN University, RIKEN Cluster for Pioneering Research, Politecnico di Milano Department of Chemistry, Materials, and Chemical Engineering ''Giulio Natta''